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		<title>Hypersensitivities, Autoimmune &amp; Immunocompromised Disorders</title>
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		<description><![CDATA[Hypersensitivities, Autoimmune and Immunocompromised Disordersv    HypersensitivityØ     Classified I-IV by:§       Source of antigen: Environmental, acquired, etc§       Time sequence:       Immediate vs. delayed§       Basic immunologic mechanism causing the injury·       Histamine release, etc.Ø     Causes§       Foods:        Chocolate, eggs, wheat, milk, nuts, seafood (iodine), strawberries§       Medications:                        Antibiotics (Major Offender)§       Dyes in diagnostic tests:       Iodine/Barium §       Animals/pets§       Venoms                              Bees, hornets, [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=sara1hays.wordpress.com&amp;blog=2848151&amp;post=17&amp;subd=sara1hays&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p><span style="font-size:11pt;font-family:'Gill Sans MT';"><b><u><span style="font-size:11pt;font-family:'Gill Sans MT';">Hypersensitivities, Autoimmune and Immunocompromised Disorders</span></u></b><span style="font-size:11pt;font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><b><u><span style="font-size:11pt;font-family:'Gill Sans MT';">Hypersensitivity</span></u></b><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Classified I-IV by:</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Source of antigen: Environmental, acquired, etc</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Time sequence: <span>      </span>Immediate vs. delayed</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Basic immunologic mechanism causing the injury</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Histamine release, etc.</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Causes</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Foods:<span>        </span>Chocolate, eggs, wheat, milk, <span>nuts, seafood (iodine),</span> strawberries</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Medications:<span>                        </span>Antibiotics (Major Offender)</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Dyes in diagnostic tests: <span>      </span>Iodine/Barium </span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Animals/pets</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Venoms<span>                              </span>Bees, hornets, wasps, spiders</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Inhalants:<span>                            </span>Allergies, Pollens, dust, cigarette smoke, pollutants<span>    </span></span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Serums: from animals:<span>         </span>Horse serum used in antitoxins</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Contactants: <span>                      </span>Tape, cosmetics</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Intrinsic:<span>                             </span>Bacteria: (G-) </span><span style="font-size:11pt;"><font face="Times New Roman">→</font></span><span style="font-size:11pt;font-family:'Gill Sans MT';">shock</span><span style="font-size:11pt;font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><b><u><span style="font-size:11pt;font-family:'Gill Sans MT';">Types of Hypersensitivity Reactions</span></u></b><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><u><span style="font-size:11pt;font-family:'Gill Sans MT';">Type I-</span></u></b><span style="font-size:11pt;font-family:'Gill Sans MT';"> IgE mediated</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Exposure to antigen </span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Bind with Mast cells—severe inflammation</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Histamine release—</span><span style="font-size:11pt;"><font face="Times New Roman">↑</font></span><span style="font-size:11pt;font-family:'Gill Sans MT';"> permeability <span> </span></span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Autonomic nervous system—Controls BP &amp; constriction <span> </span></span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Genetic predisposition—atopic </span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Life threatening—anaphylaxis only</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Desensitization—allergy shots</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><u><span style="font-size:11pt;font-family:'Gill Sans MT';">Type II-</span></u></b><span style="font-size:11pt;font-family:'Gill Sans MT';"> Tissue Specific</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Involves tissues and organs<i></i></span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><i><span style="font-size:11pt;font-family:'Gill Sans MT';">Antigen reacts with antibody</span></i><span style="font-size:11pt;font-family:'Gill Sans MT';"> on cell wall</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Antigen-antibody complexes form</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Destruction by:</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Activation of complement cascade resulting in cytolysis</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Enhanced phagocytosis</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Cytoxic T-cell interaction: b/c it thinks it will fight</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Malfunction of cell: if it doesn’t die</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><b><span style="font-size:11pt;font-family:'Gill Sans MT';">Transfusion Reaction</span></b><span style="font-size:11pt;font-family:'Gill Sans MT';">—within 15 minutes. <b><u></u></b></span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Symptoms:<b><u></u></b></span><span style="font-size:11pt;font-family:Symbol;"><span>¨<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Chills, N/V, Fever, Low back pain from kidneys!<span>       </span></span><span style="font-size:11pt;font-family:Symbol;"><span>¨<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Hypotension, Tachycardia<span>    </span></span><span style="font-size:11pt;font-family:Symbol;"><span>¨<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Shock, Anxiety<span>                    </span></span><span style="font-size:11pt;font-family:Symbol;"><span>¨<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Hyperkalemia<span>         </span></span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><u><span style="font-size:11pt;font-family:'Gill Sans MT';">Type III</span></u></b><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">2<sup>nd</sup>ary to antigen-antibody complexes</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Complexes deposited in tissues/blood vessels/joints</span><span style="font-size:11pt;"><font face="Times New Roman">→</font></span><span style="font-size:11pt;font-family:'Gill Sans MT';"> tissue damage </span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Local or systemic</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Immediate or <u>delayed</u></span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Common sites: kidneys, skin, joints</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Examples: SLE, RA</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><u><span style="font-size:11pt;font-family:'Gill Sans MT';">Type IV-</span></u></b><span style="font-size:11pt;font-family:'Gill Sans MT';"> T-Cell mediated!</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Delayed Hypersensitivity<b>: </b></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Start S&amp;S in 24 hrs, but can be months/years.<b></b></span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">T-cells</span><span style="font-size:11pt;font-family:'Gill Sans MT';"> – toxin killing mechanism</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Attack and destroy cells/multiply </span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Recruit phagocytic cells</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Example: tissue graft rejection, tuberculin reaction, allergic reactions—delayed and topical. Ex: Poison Ivy.<span>  </span>Usually localized.</span><span style="font-size:11pt;font-family:'Gill Sans MT';"> </span><span style="font-size:11pt;font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><b><u><span style="font-size:11pt;font-family:'Gill Sans MT';">Autoimmune Disorders</span></u></b><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Systemic</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Tissue specific</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Genetic susceptibility</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Environmental factors</span><span style="font-size:11pt;font-family:'Gill Sans MT';"> </span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-size:11pt;font-family:'Gill Sans MT';">Systemic Lupus Erythematosus (SLE)</span></b><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Chronic</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Inflammatory</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Deposition of immune complexes: Type III Hypersensitivity </span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Etiology</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Genetic: Women age 18-40, Blacks, and twins </span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Environmental</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Autoantibodies: against own tissues </span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Anti-nuclear antibodies (ANA)</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Anti-DNA antibodies</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Affect blood cells</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Clinical manifestations</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Facial rash—butterfly rash.<span>  </span></span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Renal problems—inflammation damages kidneys </span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Arthritis</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Presence of ANA</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Hematological disorders: </span><span style="font-size:11pt;font-family:'Book Antiqua';">↓</span><span style="font-size:11pt;font-family:'Gill Sans MT';"> WBC/RBC &amp; platelets.</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Diagnosis</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">History: Occupation, exposures as child</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">PE</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Serum analysis: Anti-DNA antibody most specific </span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Treatment:<span>  </span>All treat symptoms b/c no cure!</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">NSAIDS—<span>                                </span>Pain &amp; inflammation </span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Antimalarial medication—<span>         </span>Plaquenil </span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Corticosteroids—<span>                     </span>Anti-inflammatory </span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Immunosuppresive Meds</span><span style="font-size:11pt;font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><b><span style="font-size:11pt;font-family:'Gill Sans MT';">Host-Verses-Graft Rejection</span></b><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Pathophysiology</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">HLA antigens</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Type IV reaction <span>                </span>T-cells!</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Hyperacute rejection—<span>      </span>Immediate </span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Acute rejection—<span>               </span>days</span><span style="font-size:11pt;"><font face="Times New Roman">→</font></span><span style="font-size:11pt;font-family:'Gill Sans MT';">months.<span>  </span>Antibodies against HLA antigen</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Chronic rejection—<span>            </span>months</span><span style="font-size:11pt;"><font face="Times New Roman">→</font></span><span style="font-size:11pt;font-family:'Gill Sans MT';">years. Weak Type 4 reaction</span><span style="font-size:11pt;font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><b><span style="font-size:11pt;font-family:'Gill Sans MT';">Graft-Versus-Host Disease:</span></b><span style="font-size:11pt;font-family:'Gill Sans MT';"><span>   </span>Graft is rejecting YOU!</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Pathophysiology</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Immunocompromised transplantation—common w/ bone marrow transplant</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">GVHD development</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Functional <i>cellular</i> immune component—from T-cells</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Foreign antigens</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Immunocompromised recipient</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Acute</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Chronic</span><span style="font-size:11pt;font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><b><u><span style="font-size:11pt;font-family:'Gill Sans MT';">Immunodeficiencies</span></u></b><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-size:11pt;font-family:'Gill Sans MT';">Congenital</span></b><span style="font-size:11pt;font-family:'Gill Sans MT';">=inherited &amp; often opportunistic </span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Abnormalities in cell maturation</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Hypogammaglobulinemia—</span><span style="font-size:11pt;font-family:'Book Antiqua';">↓</span><span style="font-size:11pt;font-family:'Gill Sans MT';"> antibodies in blood </span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Severe combined immunodeficiencies (SCIDs)</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Cell mediated T-cells &amp; antibody (plasma B-cells)</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Adenosine deaminase deficiency (</span><span style="font-size:11pt;font-family:'Gill Sans MT';">ADA</span><span style="font-size:11pt;font-family:'Gill Sans MT';">)</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Lacks enzyme so toxins buildup.<span>  </span>Causes lymphocytes to not mature properly </span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Purine nucleoside phosphorylase deficiency (PNP)</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-size:11pt;font-family:'Gill Sans MT';">DeGeorge Syndrome</span></b><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">T-Cell deficiency</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Defect on chromosome 22</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Clinical manifestations</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Facial disorders</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Low set and angulated ears</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Hypocalcemia</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Chronic infections</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Treatment</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Thymus transplant</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Bone marrow transplant</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-size:11pt;font-family:'Gill Sans MT';">Selective Immunoglobulin A Deficiency</span></b><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Affects mature B cells</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Genetic</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Environmental</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Symptoms</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Asymptomatic</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">URI’s</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Allergic manifestations</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Treatment</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">None</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-size:11pt;font-family:'Gill Sans MT';">Acquired</span></b><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Nutritional</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Iatrogenic</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Trauma</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Stress</span><span style="font-size:11pt;font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><b><u><span style="font-size:11pt;font-family:'Gill Sans MT';">AIDS</span></u></b><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">HIV</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Retrovirus</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">RNA</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Reverse transcriptase</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Double stranded DNA</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">New genetic make-up</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Viremia</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Low HIV levels – 10 to 12 years (poss)</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Replicating at fast rate</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">HIV looking for CD4 receptors</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Lymphocytes</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Monocytes/macrophages</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Astrocytes</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Oligodendrocytes </span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">T cells have more CD4 receptors</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Unfortunate: T- cells play a key role in the immune system’s ability to recognize and defend itself against pathogens</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Normal CD-4 level is 800 – 1200 cells/microliter</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Normal life span = 100 days; HIV = 2 days</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Destroys 1 billion CD4 T cells every day</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Healthy immune system = CD4 T at 500 cells/microliter</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">CD4 T= 200-499 – immune problems</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">CD4 T= &lt; 200 – opportunistic infections</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Transmission of HIV</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Blood</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Semen and Vaginal fluid</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Breast milk</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Saliva</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Tears</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Sweat</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Insects</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Variables for Transmission</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Duration &amp; frequency of contact</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Volume of fluid</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Virulence &amp; concentration of the organism</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Host immune status</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-size:11pt;font-family:'Gill Sans MT';">Primary Infection Phase</span></b><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">High viral load</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Dramatic drop in CD4 cell counts</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Flu-like symptoms</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Window period</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Antibodies develop (usually can be detected in 4-12 weeks)<span> </span></span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-size:11pt;font-family:'Gill Sans MT';">Latency Phase: Initial</span></b><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Asymptomatic phase</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Vague symptoms</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">CD4 T count &gt; 500 cells/microliter</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">High risk </span><span style="font-size:11pt;font-family:Wingdings;"><span>à</span></span><span style="font-size:11pt;font-family:'Gill Sans MT';"> even though no symptoms, can still transmit HIV to others</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-size:11pt;font-family:'Gill Sans MT';">Latency Phase: Intermediate</span></b><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Asymptomatic but virus is replicating</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">May have recurrent infections of sinuses/respiratory tract, ^ fatigue</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">CD4 T counts continue to fall – between 200-500</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Damage to lymphatic structures </span><span style="font-size:11pt;font-family:Wingdings;"><span>à</span></span><span style="font-size:11pt;font-family:'Gill Sans MT';"> loose ability to<span>  </span>contain destructive HIV</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-size:11pt;font-family:'Gill Sans MT';">Latency Phase: Late</span></b><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Continued decrease of CD-4 Cells</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Occurrence of opportunistic infections</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Oropharyngeal candidal infection</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Shingles</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">P. carinii pneumonia</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Oral/genital herpes</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Kaposi Sarcoma</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Oral hairy leukoplakia</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-size:11pt;font-family:'Gill Sans MT';">Overt AIDS Phase</span></b><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Diagnosis of AIDS (Acquired Immunodeficiency Syndrome)</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Immune system becomes severely compromised</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">CDC Diagnostic criteria for AIDS= HIV positive</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">At least one of: </span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">CD4+ below 200/ul.</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Opportunistic infection</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Development of opportunistic cancer</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Wasting syndrome occurs (loss of 10% ideal body mass)</span><span style="font-size:11pt;font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Dementia </span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Diagnosis</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">HIV antibody test (ELISA)</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Western Blot Assay</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">PCR</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">OraSure test</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Ora Quick Rapid HIV-1 Antibody Test</span><span style="font-size:11pt;font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Treatment</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><b><span style="font-size:11pt;font-family:'Gill Sans MT';">NO CURE</span></b><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Anti-Retroviral medication= HAART</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Drugs</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Antibiotics</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Antifungals</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Vaccines</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Influenza</span><span style="font-size:11pt;font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-size:11pt;font-family:'Gill Sans MT';">Pneumonia</span><span style="font-size:11pt;font-family:'Gill Sans MT';"> </span></span></p>
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		<title>HIV and Immune System Pharmacology</title>
		<link>http://sara1hays.wordpress.com/2008/02/24/hiv-and-immune-system-pharmacology/</link>
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		<pubDate>Sun, 24 Feb 2008 19:09:59 +0000</pubDate>
		<dc:creator>sara1hays</dc:creator>
				<category><![CDATA[Patho/Pharm]]></category>

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		<description><![CDATA[HIV and Immune System Pharmacologyv    MOAØ     Nucleoside Reverse Transcriptinase Inhibitors (NRTI’s) §       Mimics neucleocides needed to convert RNA→DNA &#38; Inhibits enzyme Ø     NonNucleoside Reverse Transcriptinase Inhibitors (NNRTI’s)§       Binds near active site to inactivates reverse transcriptase enzymeØ     Protease Inhibitors (PI’s)§       Inhibit protease enzyme needed from DNA at tail end of process.  §       Prevents new RNA virus [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=sara1hays.wordpress.com&amp;blog=2848151&amp;post=16&amp;subd=sara1hays&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p><b><u><span style="font-family:'Gill Sans MT';">HIV and Immune System Pharmacology</span></u></b><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><span style="font-family:'Gill Sans MT';">MOA</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-family:'Gill Sans MT';">Nucleoside Reverse Transcriptinase Inhibitors (NRTI’s)</span></b><span style="font-family:'Gill Sans MT';"> </span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Mimics neucleocides needed to convert RNA</span><font face="Times New Roman">→</font><span style="font-family:'Gill Sans MT';">DNA &amp; Inhibits enzyme </span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-family:'Gill Sans MT';">NonNucleoside Reverse Transcriptinase Inhibitors (NNRTI’s)</span></b><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Binds near active site to inactivates reverse transcriptase enzyme</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-family:'Gill Sans MT';">Protease Inhibitors (PI’s)</span></b><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Inhibit protease enzyme needed from DNA at tail end of process.<span>  </span></span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Prevents new RNA virus from splitting </span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-family:'Gill Sans MT';">Fusion Inhibitors</span></b><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Targets 1<sup>st</sup> step w/ fusion &amp; initial entry w/ cell</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Tie up CD4 receptor site so virus can’t latch on</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Last-ditch effort </span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><span style="font-family:'Gill Sans MT';">Therapy recommendations</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Single-Drug: Ineffective</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">HAART: Highly Active Antiretrovial Therapy</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Combinations of RT’s and PI’s into nice cocktail</span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><span style="font-family:'Gill Sans MT';">Indications</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Active HIV</span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><span style="font-family:'Gill Sans MT';">Contraindications</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Severe allergy: weigh pros/cons</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Intolerable toxicity:<span>  </span>N/V, diarrhea, rash, pancreatitis, liver/kidney toxicity, bone marrow depression, hepatitis patients </span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><span style="font-family:'Gill Sans MT';">Side Effects/Adverse Effects</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Same and nonretroviral: nausea, vomiting, diarhea</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Tolerate: Strict drug schedule.</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Myalgias/ joint pain</span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><span style="font-family:'Gill Sans MT';">Drug interactions</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">MULTIPLE!!<span>  </span>Look up!</span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><span style="font-family:'Gill Sans MT';">Specific Agents</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-family:'Gill Sans MT';">NRTI’s: </span></b><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><i><span style="font-family:'Gill Sans MT';">Zidovudine (AZT, Retrovir): </span></i><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Newborns with HIV mom<span>  </span></span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Post-exposure prophylaxis</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><i><span style="font-family:'Gill Sans MT';">Lamivudine (Epivir): </span></i><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Rapid </span><span style="font-family:'Gill Sans MT';">PO</span><span style="font-family:'Gill Sans MT';"> absorption. </span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Bactrim </span><font face="Times New Roman">↑ </font><span style="font-family:'Gill Sans MT';">level to toxicicity.<span>  </span></span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><i><span style="font-family:'Gill Sans MT';">Tenovir (Viread): </span></i><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Book Antiqua';">↓</span><span style="font-family:'Gill Sans MT';"> effecacy of PI’s </span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-family:'Gill Sans MT';">NNRTI’s</span></b><span style="font-family:'Gill Sans MT';">: Great </span><span style="font-family:'Gill Sans MT';">PO</span><span style="font-family:'Gill Sans MT';"> &amp; heavily metabolized by cytochrome P450 system </span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><i><span style="font-family:'Gill Sans MT';">Delavirdine (Rescriptor): </span></i><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Nasty rash </span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><i><span style="font-family:'Gill Sans MT';">Efavirenz (Sustiva): </span></i><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Psychiatric problems </span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><i><span style="font-family:'Gill Sans MT';">Nevirapine (Viramune):</span></i><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Stevens-Johnson Syndrome</span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">No women with CD4 count </span><span style="font-family:'Book Antiqua';">↓</span><span style="font-family:'Gill Sans MT';"> 200- hepatotoxicity risk </span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-family:'Gill Sans MT';">Protease Inhibitors (PI’s):</span></b><span style="font-family:'Gill Sans MT';"> ∆ fat distribution, </span><font face="Times New Roman">↑</font><span style="font-family:'Gill Sans MT';"> cholesterol &amp; blood sugars</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Amprenavir </span><span style="font-family:'Gill Sans MT';">(<span>Agenerase</span>): <span>          </span>Take w/ fatty meal</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Nelfinavir (Viracept</span><span style="font-family:'Gill Sans MT';">): <span>      </span>Take w/ fatty meal</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Indinavir (Crixivan</span><span style="font-family:'Gill Sans MT';">): <span>       </span>Kidney stones. Combo w/ 2 retrovirals. </span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Lopinavir/ritonavir (Kaletra</span><span style="font-family:'Gill Sans MT';">): <span>     </span>Ritonavir </span><span style="font-family:'Book Antiqua';">↓</span><span style="font-family:'Gill Sans MT';"> metabolism of lopinavir<span>  </span></span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-family:'Gill Sans MT';">Fusion Inhibitors: </span></b><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Enfuvirtide (Fuzeon): <span>      </span>Limited usage—last efforts</span><span style="font-family:'Gill Sans MT';"> </span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><b><u><span style="font-family:'Gill Sans MT';">Immunosuppressant Agents</span></u></b><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">MOA:</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Varies</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Suppress certain T lymphocyte cells w/ cellular immunity </span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Indications</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Organ rejection prevention</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">SLE-lupus</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">RA</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Psoriasis</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">IBS</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Crones Disease </span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Contraindications</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Allergy</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Relative</span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Renal/hepatic failure</span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Pregnancy &amp; teratogens </span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Side Effects/Adverse Effects</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Susceptibility to infection</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Hepatotoxcitity!</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Interactions</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><b><u><span style="font-family:'Gill Sans MT';">Cyclosporine</span></u></b><span style="font-family:'Gill Sans MT';"> has many</span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Cardiovascular meds: <span>                     </span></span><font face="Times New Roman">↑</font><span style="font-family:'Gill Sans MT';"> cyclosporine level </span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Cytochrome P-450 system </span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Nephrotoxic agents</span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">HIV agents </span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Anti-infectives: <span>                   </span></span><font face="Times New Roman">↑</font><span style="font-family:'Gill Sans MT';"> cyclosporine levels</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Specific Agents</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><i><span style="font-family:'Gill Sans MT';">Cyclosporine (Neoral)</span></i><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Post-transplant </span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">RA &amp; psoriasis </span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><i><span style="font-family:'Gill Sans MT';">Azathioprine (Imuran)</span></i><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Book Antiqua';">↓</span><span style="font-family:'Gill Sans MT';"> B <i>&amp;</i> T cell production </span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Severe RA &amp; kidney transplant</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><i><span style="font-family:'Gill Sans MT';">Basiliximab (Simulect)</span></i><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Interleukin 2 antagonist w/ complement cascade</span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Perioperative care w/ kidney transplants</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><i><span style="font-family:'Gill Sans MT';">Sirolimus (Rapamune)</span></i><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Book Antiqua';">↓</span><span style="font-family:'Gill Sans MT';"> T-cell function</span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Combo w/ steriods/Cyclosporin for kidney transplants</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><i><span style="font-family:'Gill Sans MT';">Mycophnolate mofetil (CellCept)</span></i><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Book Antiqua';">↓</span><span style="font-family:'Gill Sans MT';"> B &amp; T cells</span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Renal/Heart transplants</span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Combo w/ steroids/Cyclosporin</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><i><span style="font-family:'Gill Sans MT';">Tacrolimus (Prograf)</span></i><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Inhibits T-cell activation<i></i></span><span style="font-family:Symbol;"><span>·<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Liver/Kidney transplants…</span><font face="Times New Roman">↑</font><span style="font-family:'Gill Sans MT';"> Nephrotoxicity w/ Cyclosporin </span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Special Considerations</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Contact with others </span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Pregnancy</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Leukocyte count- </span><span style="font-family:'Book Antiqua';">↓</span><span style="font-family:'Gill Sans MT';"> 3,000 dangerous</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">RBC counts</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Children</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Co-morbidities</span><span style="font-family:'Gill Sans MT';"> </span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><b><u><span style="font-family:'Gill Sans MT';">Immunizing Agents</span></u></b><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-family:'Gill Sans MT';">Toxoids</span></b><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Inactivated bacterial toxins</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Usually enough to stimulate antibody response</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Immunity may not be lifelong b/c toxoid inactivated</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-family:'Gill Sans MT';">Vaccines</span></b><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Usually lifelong</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Not as strong as live vaccine, may require boosters</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Live vaccines usually attenuated (weakened) of bacteria/virus which sets off immune system.<span>  </span>Can have lifelong immunity. </span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><b><span style="font-family:'Gill Sans MT';">Immunoglobulin Therapy</span></b><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Passive immunity where we give you antibodies to help pt fight.<span>  </span></span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><span style="font-family:'Gill Sans MT';">MOA: </span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Immune response</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Active: Vaccines and toxoids</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Passive: Immunoglobulins: need quick antibodies</span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><span style="font-family:'Gill Sans MT';">Indications</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Immunity</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Temporary protection</span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><span style="font-family:'Gill Sans MT';">Contraindications</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Allergies</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Toxin</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Synthetic components: Many ppl allergic to synthetic components and not toxoid itself. Ex: egg product/horses</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Febrile illness</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Important for kids b/c many immunizations when children.<span>  </span>Immune system already busy.<span>  </span>Kids that are febrile PRIOR to getting med.</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Immunocompromised state</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Don’t give any LIVE vaccine to these</span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><span style="font-family:'Gill Sans MT';">Side Effects</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Fever AFTER immunization</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Soreness at injection site</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Expect to go away after few days</span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><span style="font-family:'Gill Sans MT';">Adverse Effects</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><i><span style="font-family:'Gill Sans MT';">Serum Sickness</span></i><span style="font-family:'Gill Sans MT';">: Caused by equine vaccines/toxins that causes laryngeal swelling/tongue and facial edema, and rash </span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><span style="font-family:'Gill Sans MT';">Special Populations</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Preterm infants-</span><span style="font-family:'Gill Sans MT';"> (if child born 2 weeks premature and is 4 wks old, really only 2 weeks old.)<span>  </span>Immunize based on REAL birthday. </span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Pregnancy</span><span style="font-family:'Gill Sans MT';">: <span> </span>Never give live vaccines. After 1<sup>st</sup> trimester if necessary.</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Limited Immunodeficient</span><span style="font-family:'Gill Sans MT';">: Not immunocompromized but immunodificient. ARE able to receive vaccines. </span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Active disease</span><span style="font-family:'Gill Sans MT';">: Want to give <i>toxoids</i> (=killed bacteria)/<i>killed vaccines</i> /immunoglobulins.<span>  </span></span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><span style="font-family:'Gill Sans MT';">Specific Agents (active)</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><u><span style="font-family:'Gill Sans MT';">Haemophilus influenzae (Hib</span></u><u><span style="font-family:'Gill Sans MT';">)</span></u><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Only vaccinate for kids under 5</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Cause meningitis, epiglotitis </span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><u><span style="font-family:'Gill Sans MT';">Hepatitis B (Recombivax</span></u><u><span style="font-family:'Gill Sans MT';">)</span></u><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">What we get.<span>  </span>Get boosters.<span>  </span></span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><u><span style="font-family:'Gill Sans MT';">Influenza (FluShield</span></u><u><span style="font-family:'Gill Sans MT';">)</span></u><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Live immunization</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><u><span style="font-family:'Gill Sans MT';">Measles, mumps, rubella (MMR II</span></u><u><span style="font-family:'Gill Sans MT';">)</span></u><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Viral illnesses.<span>  </span>Have boosters</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Not recommended/contraindicated w/ pregnant womem</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><u><span style="font-family:'Gill Sans MT';">Diptheria, tetanus, and pertussis (DTaP</span></u><u><span style="font-family:'Gill Sans MT';">)</span></u><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Both Toxoids.<span>  </span>Pertussis is inactivated, but back in gear.<span>  </span></span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><u><span style="font-family:'Gill Sans MT';">Pneumococcal (Pneumovax)</span></u><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Fights pneumococcal pnemonia, but other pneumococcal.<span>  </span>Don’t call “pnemonia vaccine” b/c fights other stuff.<span>  </span>Given to those over age 65 and few kids. 23 strains.</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><u><span style="font-family:'Gill Sans MT';">Polio (IPV</span></u><span style="font-family:'Gill Sans MT';">)</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Completely inactivated b/c very dangerous</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><u><span style="font-family:'Gill Sans MT';">Varicella (Varivax</span></u><span style="font-family:'Gill Sans MT';">)</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Live; childhood immunization.<span>  </span>Pts older than 13 and never been exposed to chickenpox or vaccinated, may give this.<span>  </span></span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><u><span style="font-family:'Gill Sans MT';">Meningococcal (Menomune</span></u><span style="font-family:'Gill Sans MT';">)</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Ppl in dorms.</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><u><span style="font-family:'Gill Sans MT';">Rabies (Imovax</span></u><span style="font-family:'Gill Sans MT';">)</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Kills quickly.<span>  </span>If body can’t fight, die in 3 days.</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Only get it if you’ve had risk for exposure.<span>  </span></span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><u><span style="font-family:'Gill Sans MT';">HPV (Gardasil</span></u><span style="font-family:'Gill Sans MT';">)</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Very common. STD ONLY!!<span>  </span>Protect with strains that lead to cervical cancer. Men always asymtomatic.<span>  </span>Given w/ ages 9-26.<span>  </span></span><span style="font-family:Wingdings;"><span>v<span style="font:7pt 'Times New Roman';">    </span></span></span><span style="font-family:'Gill Sans MT';">Passive: (many times combo w/ active)</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Hepatitis B immune globulin (H-BIG2)</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Immune globulin (Gammagard)</span><span style="font-family:Wingdings;"><span>§<span style="font:7pt 'Times New Roman';">       </span></span></span><span style="font-family:'Gill Sans MT';">Just IgG that’s powerful with fighting infection.</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Rabies immune globulin (RIG)</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Tetanus immune globulin (Hyper-Tet)</span><span style="font-family:Wingdings;"><span>Ø<span style="font:7pt 'Times New Roman';">     </span></span></span><span style="font-family:'Gill Sans MT';">Varicella zoster immune globulin (VZIG)</span><span style="font-family:'Gill Sans MT';"> </span></p>
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		<title>Role of the Nurse</title>
		<link>http://sara1hays.wordpress.com/2008/02/23/role-of-the-nurse/</link>
		<comments>http://sara1hays.wordpress.com/2008/02/23/role-of-the-nurse/#comments</comments>
		<pubDate>Sat, 23 Feb 2008 19:35:13 +0000</pubDate>
		<dc:creator>sara1hays</dc:creator>
				<category><![CDATA[Human Needs]]></category>

		<guid isPermaLink="false">http://sara1hays.wordpress.com/?p=15</guid>
		<description><![CDATA[Role of the Nurse: Provider of care- direct care or delegated care supervision. (LVN, Tech eg. initial teaching is required by the RN to do. Admin. meds, and blood is also for RN to do. Communicator- (includes education) Consumer of research and information-(utilizing the current evidence-based information to deliver care) Manager- other nurses, ourselves, eg. [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=sara1hays.wordpress.com&amp;blog=2848151&amp;post=15&amp;subd=sara1hays&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<ul>
<li>Role of the Nurse:
<ul>
<li>Provider of care- direct care or delegated care supervision. (LVN, Tech
<ul>
<li>eg. initial teaching is required by the RN to do. Admin. meds, and blood is also for RN to do.</li>
</ul>
</li>
<li>Communicator- (includes education)</li>
<li>Consumer of research and information-(utilizing the current evidence-based information to deliver care)</li>
<li>Manager- other nurses, ourselves, eg. case manager-plan of care-pt. family, social work, pt/ot, pharmacists.</li>
</ul>
</li>
<li>Nursing Process: ADPIE
<ul>
<li>Assessment</li>
<li>Analysis (Diagnosis)</li>
<li>Planning</li>
<li>Implementation</li>
<li>Evaluation: Did the intervention work? yes-outcome met; partially met-need to reassess; no-outcome not met.</li>
</ul>
</li>
<li>Evidence-Based Practice &#8211;research; conscientious use of the best evidence (i.e. findings from research, quality improvement, and practice management initiatives, and patient assessment) in combo with clinical decision making.</li>
<li>Roles: Safe and effective care; safety and infection control; health promotion and maintenance; psychosocial integrity; maintaining physiological integrity; pharmacological therapy; spiritual care.</li>
</ul>
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		<title>Human Needs</title>
		<link>http://sara1hays.wordpress.com/2008/02/23/human-needs/</link>
		<comments>http://sara1hays.wordpress.com/2008/02/23/human-needs/#comments</comments>
		<pubDate>Sat, 23 Feb 2008 19:10:37 +0000</pubDate>
		<dc:creator>sara1hays</dc:creator>
				<category><![CDATA[Human Needs]]></category>

		<guid isPermaLink="false">http://sara1hays.wordpress.com/?p=13</guid>
		<description><![CDATA[Holistic-physiological, psychological, social, spiritual Nursing- the dx and treatment of human resources to actual and potential health problems. Health-each human exists on a health-illness continuum that may move from high level of wellness to severe illness and death. Role of the Nurse-Assist individuals, families, and communities to attain the highest level of health possible&#8211;through assisting [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=sara1hays.wordpress.com&amp;blog=2848151&amp;post=13&amp;subd=sara1hays&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<ul>
<li>Holistic-physiological, psychological, social, spiritual<a href="http://sara1hays.files.wordpress.com/2008/02/maslows-hierarchy-of-needsjpg.png" title="Maslow’s Hierarchy of Needs"></a></li>
<li>Nursing- the dx and treatment of human resources to actual and potential health problems.</li>
<li>Health-each human exists on a health-illness continuum that may move from high level of wellness to severe illness and death.</li>
<li>Role of the Nurse-Assist individuals, families, and communities to attain the highest level of health possible&#8211;through assisting them to meet their various health related needs.
<ul>
<li>Levels of prevention:
<ul>
<li>Primary Prevention:<br />
CONCERNED WITH THE PREVENTION OR DELAY OF THE ACTUAL OCCURRENCE OF A SPECIFIC ILLNESS OR DISAESE.<br />
Example: maintenance of diet, body weight; safe sex; cessation of smoking; limiting alcohol intakeSecondary Prevention:<br />
PROMOTE EARLY DETECTION (case finding and screening) AND EARLY TREATMENT OF DISEASE<br />
Example: breast self-exam; TB screening; newborn screening; genetic counselingTertiary Prevention:<br />
DIRECTED TOWARD PREVENTION OF COMPLICATION AND REHABILITATION AFTER THE DISEASE<br />
Goal: support adaptation to risk; optimal reconstitution; ad Establishment of wellness.</li>
</ul>
</li>
<li>Theories of illness causation derive from the underlying cognitive orientation of a cultural group, and therapeutic practice usually follows the same cultural logic.</li>
<li>Wellnes- is a balance; dynamic state (always changing)</li>
<li>Illness- a state of homeostatic imbalance in which needs are not specifically met.</li>
<li>Maslow&#8217;s Hierarchy of Needs-</li>
<li><a href="http://sara1hays.files.wordpress.com/2008/02/maslows-hierarchy-of-needsjpg.png" title="Maslow’s Hierarchy of Needs"><img src="http://sara1hays.files.wordpress.com/2008/02/maslows-hierarchy-of-needsjpg.thumbnail.png?w=455" alt="Maslow’s Hierarchy of Needs" /></a></li>
<li>Acute/Chronic Illness-6 months or longer</li>
</ul>
</li>
</ul>
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			<media:title type="html">Maslow’s Hierarchy of Needs</media:title>
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		<title>Nutrition, Health &amp; Pregnancy</title>
		<link>http://sara1hays.wordpress.com/2008/02/12/nutrition-health-pregnancy/</link>
		<comments>http://sara1hays.wordpress.com/2008/02/12/nutrition-health-pregnancy/#comments</comments>
		<pubDate>Tue, 12 Feb 2008 01:59:31 +0000</pubDate>
		<dc:creator>sara1hays</dc:creator>
				<category><![CDATA[Childbearing Family]]></category>

		<guid isPermaLink="false">http://sara1hays.wordpress.com/2008/02/12/nutrition-health-pregnancy/</guid>
		<description><![CDATA[Body Mass &#38; Health Mesurements BMI does not distinguish fat from lean muscle Waist to Hip ratio: Max-0.8 (Cardiovascular health) FBS (fasting blood sugar) , TG&#8217;s (Triglycerides), HDL Weight Charts Set to correspond with the lowest mortality rates Not factored for lifestyle Optimum BMI: 19.8-24.5 (2 fold risk); 21-27  Mortality &#38; Weight Positive correlation between weight and [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=sara1hays.wordpress.com&amp;blog=2848151&amp;post=10&amp;subd=sara1hays&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<blockquote><p><a href="http://sara1hays.files.wordpress.com/2008/02/mypyramid.jpg" title="My Pyramid"></a><a href="http://sara1hays.files.wordpress.com/2008/02/dailyrecommendationsduringpreg.jpg" title="dailyrecommendationsduringpreg.jpg"></a><a href="http://sara1hays.files.wordpress.com/2008/02/nutrition.jpg" title="nutrition.jpg"><img src="http://sara1hays.files.wordpress.com/2008/02/nutrition.jpg?w=455" alt="nutrition.jpg" /></a></p></blockquote>
<ul>
<li>
<div><strong>Body Mass &amp; Health Mesurements</strong></div>
<ul>
<li>
<div>BMI does not distinguish fat from lean muscle</div>
</li>
<li>
<div>Waist to Hip ratio: Max-0.8 (Cardiovascular health)</div>
</li>
<li>
<div>FBS (fasting blood sugar) , TG&#8217;s (Triglycerides), HDL</div>
</li>
</ul>
</li>
<li>
<div><strong>Weight Charts</strong></div>
<ul>
<li>
<div>Set to correspond with the lowest mortality rates</div>
</li>
<li>
<div>Not factored for lifestyle</div>
</li>
<li>
<div>Optimum BMI: 19.8-24.5 (2 fold risk); 21-27 </div>
</li>
</ul>
</li>
<li>
<div><strong>Mortality &amp; Weight</strong></div>
<ul>
<li>
<div>Positive correlation between weight and mortality. Controlled for smoking. (one goes up/other goes up)</div>
</li>
<li>
<div>Mortality rates up to 35% or higher with BMI greater than 25.</div>
</li>
</ul>
</li>
<li>
<div><strong>Chronic Disease &amp; BMI</strong></div>
<ul>
<li>
<div>Type 2-diabetes</div>
</li>
<li>
<div>Hypertension</div>
</li>
<li>
<div>Chronic Heart Disease</div>
</li>
<li>
<div>Cholelithisais</div>
</li>
<li>
<div>Postmenopausal breast cancer&#8211;all breast cancer</div>
</li>
<li>
<div>Cancer</div>
</li>
</ul>
</li>
<li>
<div>Even a gain of 11-22 lbs. can result in an increased RR-Relative Risk of 1.5 to 3 for Chronic Heart Disease, Diabetes, &amp; Hypertension</div>
<ul>
<li>
<div>Relative Risk:</div>
<ul>
<li>
<div>1.0 = no increase risk; standard</div>
</li>
<li>
<div>1.5 = 50% risk over population</div>
</li>
<li>
<div>2.0 = 100% risk over population</div>
</li>
</ul>
</li>
</ul>
</li>
<li>
<div>MyPyramid.gov <a href="http://sara1hays.files.wordpress.com/2008/02/mypyramid.jpg" title="My Pyramid"><img src="http://sara1hays.files.wordpress.com/2008/02/mypyramid.thumbnail.jpg?w=455" alt="My Pyramid" /></a></div>
</li>
<li>
<div><strong>Pre-Pregnancy BMI &amp; (Weight gain recommendations) </strong></div>
<ul>
<li>
<div>less than 19.8 = underweight (28-40lbs)</div>
</li>
<li>
<div>19.8-24.9 = normal weight (25-35lbs)</div>
</li>
<li>
<div>25.0-29.9 = overweight (15-25lbs)</div>
</li>
<li>
<div>equal to/above 30 = obese (less than/equal to 15lbs)</div>
<ul>
<li>
<div><em>Twins range= 35-45lbs</em></div>
</li>
<li>
<div><em>Higher end of range for young/black/S.Asian women</em></div>
</li>
</ul>
</li>
</ul>
</li>
<li>
<div><strong>High risk for poor weight gain groups</strong></div>
<ul>
<li>
<div>Smokers</div>
</li>
<li>
<div>Substance users</div>
</li>
<li>
<div>Very young adolesants</div>
</li>
<li>
<div>Poor</div>
</li>
<li>
<div>Busy professional women</div>
</li>
<li>
<div>Multiple gestation</div>
</li>
</ul>
</li>
<li>
<div><strong>Pregnancy Risk Related to Overweight</strong></div>
<ul>
<li>
<div>hypertension</div>
</li>
<li>
<div>diabetes</div>
</li>
<li>
<div>Cesarean</div>
</li>
<li>
<div>Macrosomia (too big)</div>
</li>
<li>
<div>Shoulder Dystocia (baby shoulder caught)</div>
</li>
<li>
<div>NTD (neural tube defect)</div>
</li>
<li>
<div>Late intrauterine death</div>
</li>
<li>
<div>Infection</div>
</li>
</ul>
</li>
<li>
<div><strong>Distribution of weight in pregnancy:</strong></div>
<ul>
<li>
<div>7.5-8.5lbs = fetus</div>
</li>
<li>
<div>7.5lbs = fat &amp; protein</div>
</li>
<li>
<div>4.0lbs = blood</div>
</li>
<li>
<div>2.7lbs = tissue fluids</div>
</li>
<li>
<div>2.0lbs = uterus</div>
</li>
<li>
<div>1.8lbs = amniotic fluid</div>
</li>
<li>
<div>1.5lbs = placenta &amp; umbilical cord</div>
</li>
<li>
<div>1.0lbs = breasts</div>
</li>
<li>
<div>TOTAL = 28-29lbs</div>
</li>
</ul>
</li>
<li>
<div><strong>Weight gain &amp; birth weight</strong></div>
<ul>
<li>
<div>when weight gain is within IOM (Institute of Medicine) recommendations incidence of SGA or LBW is reduced.</div>
</li>
</ul>
</li>
<li>
<div><strong>Calorie Requirements:</strong></div>
<ul>
<li>
<div>After 20 weeks, ADD 300 CALORIES, and 25 GRAMS of PROTEIN to the woman&#8217;s non-preg calorie and protein requirements.</div>
</li>
</ul>
</li>
<li>
<div><strong>Risk associated with LBW</strong></div>
<ul>
<li>
<div>Mortality</div>
</li>
<li>
<div>Mental retardation</div>
</li>
<li>
<div>Cerebral palsy</div>
</li>
<li>
<div>Learning disabilities</div>
</li>
<li>
<div>Neurologic defects</div>
</li>
<li>
<div>Vision/Hearing impairments</div>
</li>
<li>
<div>Stunted growth and development</div>
</li>
</ul>
</li>
<li>
<div><strong>Brain growth</strong></div>
<ul>
<li>
<div>malnutrition during hyperplasia leads to a decrease in the number of brain cells that is irreversible.</div>
</li>
<li>
<div>BW of 3000 grams is critical</div>
</li>
</ul>
</li>
<li>
<div><strong>Alcohol:</strong> No known safe level. Avoid all alcohol including beer and wine</div>
</li>
<li>
<div><strong>Caffine &amp; Pregnancy:</strong> Half-Life prolonged in the fetus; fine, but do not overdue it; 300mg-400mg/day = SAFE amount of coffee and soft drinks</div>
</li>
<li>
<div>Pregnancy Requirements:</div>
<ul>
<li>
<div>300Kcal/day</div>
</li>
<li>
<div>25-60grams protein/day</div>
</li>
<li>
<div>Iron 30mg/day beginning at 12th week</div>
</li>
<li>
<div>Folate 400mcg/day</div>
</li>
<li>
<div>Calcium 1200mg/day (dairy, spinich, supplements)</div>
</li>
</ul>
</li>
<li>
<div align="left">Sources of IRON:</div>
<ul>
<li>
<div align="left">not enough can cause&#8211;anemia</div>
</li>
<li>
<div align="left">Liver, meats, whole grain or enriched breads and cereals, deep green leafy vegetables, legumes, dried fruits</div>
</li>
<li>
<div align="left">take on an empty stomach</div>
</li>
<li>
<div align="left">may cause stools to be black/green</div>
</li>
</ul>
</li>
<li>
<div align="left">Sources of CALCIUM:</div>
<ul>
<li>
<div align="left">Milk &amp; Yogurt &#8211;rich in Ca+</div>
</li>
<li>
<div align="left">Milk, cheese, yogurt, sardines or other fish eaten with bones left in, deep green leafy vegetables except spinach or Swiss chard, calcium-set tofu, baked beans, tortillas</div>
</li>
<li>
<div align="left">Daily Recommendations During Pregnancy <a href="http://sara1hays.files.wordpress.com/2008/02/dailyrecommendationsduringpreg.jpg" title="dailyrecommendationsduringpreg.jpg"><img src="http://sara1hays.files.wordpress.com/2008/02/dailyrecommendationsduringpreg.thumbnail.jpg?w=455" alt="dailyrecommendationsduringpreg.jpg" /></a></div>
</li>
</ul>
</li>
<li>
<div align="left">Nutrition &amp; Prenatal Care</div>
<ul>
<li>
<div align="left">24hr recall</div>
</li>
<li>
<div align="left">Cultural sensitivity</div>
</li>
<li>
<div align="left">Consistancy weighing</div>
</li>
<li>
<div align="left">Set weight goal at initial visit</div>
</li>
<li>
<div align="left">Additional time with high risk groups</div>
</li>
</ul>
</li>
<li>
<div align="left">Morning Sickness:</div>
<ul>
<li>
<div align="left">Dry crackers/starches</div>
</li>
<li>
<div align="left">Upright after meals</div>
</li>
<li>
<div align="left">Eat slowly</div>
</li>
<li>
<div align="left">Small frequent meals</div>
</li>
<li>
<div align="left">Ginger</div>
</li>
</ul>
</li>
</ul>
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		<title>Diagnosis of Pregnancy</title>
		<link>http://sara1hays.wordpress.com/2008/02/12/diagnosis-of-pregnancy/</link>
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		<pubDate>Tue, 12 Feb 2008 01:36:41 +0000</pubDate>
		<dc:creator>sara1hays</dc:creator>
				<category><![CDATA[Childbearing Family]]></category>

		<guid isPermaLink="false">http://sara1hays.wordpress.com/?p=5</guid>
		<description><![CDATA[Signs &#38; Symptoms of Pregnancy: **Objective 1: Identify the presumptive, probable and positive signs of pregnancy  Presumptive Signs:[Pregnant woman notices] Maternal physiological changes that a woman may experience. Abrupt cessation of menses Nausea and vomiting Tingling, tenseness, nodularity, and enlargement of breasts and nipples Increased frequency of urination Fatigue Color changes of breast:  darkening of nipples; [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=sara1hays.wordpress.com&amp;blog=2848151&amp;post=5&amp;subd=sara1hays&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p><span style="font-size:12pt;"><font face="Times New Roman"><a href="http://sara1hays.files.wordpress.com/2008/02/gestationalwheel.gif" title="Gestational Wheel"></a><span><a href="http://sara1hays.files.wordpress.com/2008/02/gestationalwheel.gif" title="Gestational Wheel"></a><strong><a href="http://sara1hays.files.wordpress.com/2008/02/gestationalwheel1.gif" title="Gestational Wheel"></a>Signs &amp; Symptoms of Pregnancy:</strong></span></font></span></p>
<p><span style="font-size:12pt;"><font face="Times New Roman"><span></span><strong><em><span style="font-size:9pt;font-family:Tahoma;">**Objective 1:</span></em><span> <i>Identify the presumptive, probable and positive signs of pregnancy</i> </span></strong></font></span><span style="font-size:12pt;"><font face="Times New Roman"> </font></span><span style="font-size:12pt;"><font face="Times New Roman"></font></span><span style="font-size:12pt;"><font face="Times New Roman"></p>
<ul>
<li class="MsoNormal"><span><strong>Presumptive Signs:[Pregnant woman notices]</strong> Maternal physiological changes that a woman may experience.</span>
<ul>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Abrupt cessation of menses</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Nausea and vomiting<a href="http://sara1hays.files.wordpress.com/2008/02/gestationalwheel.gif" title="Gestational Wheel"></a></span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Tingling, tenseness, nodularity, and enlargement of breasts and nipples</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Increased frequency of urination</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Fatigue</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Color changes of breast:  darkening of nipples; primary and secondary areolar changes</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Appearance of </span><span style="font-size:9pt;font-family:Tahoma;">Montgomery</span><span style="font-size:9pt;font-family:Tahoma;">’s tubercles (glands, breast-around nipple)</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Continued elevation of BBT in the absence of infection</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Expression of colostrom from nipples (3rd trimester)</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Excessive salivation </span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Quickening (first feel the baby move)</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Skin pigmentation and conditions, e.g. chloasma, breast and abdominal striae, linea nigra, vascular spiders, palmar erythema</span></li>
</ul>
</li>
<li class="MsoNormal"><span><strong>Probable Signs: [RN Notices]</strong> Maternal physiological and anatomical changes detected upon examination (other than presumptive signs)</span>
<ul>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Chadwick’s sign</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Enlargement of abdomen</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Change in the shape of the uterus</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Ballotment (pateller test)</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Palpation of fetal outline</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Fetal movement palpated (probable or positive)</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Piskacek’s sign</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Hegar’s sign</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Goodell’s sign</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Palpation of Braxton Hicks contractions</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Positive pregnancy test</span></li>
</ul>
</li>
<li class="MsoNormal"><span><strong>Positive Signs:</strong> Directly attributed to the fetus as documented by the examiner</span>
<ul>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">*ONLY* Fetal heart tones</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Ultrasound confirmation</span></li>
</ul>
</li>
</ul>
<p><span style="font-size:9pt;font-family:Tahoma;"> **<strong><i>Objective 2: Differentiate between quantitative and qualitative pregnancy tests</i></strong></span></p>
<ul>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Ask ahead of time: &#8220;How would you feel about being pregnant right now?&#8221;</span></li>
<li class="MsoNormal"><span><strong>Pregnancy Tests</strong>:  </span></li>
<li class="MsoNormal"><span></span><span style="font-size:9pt;font-family:Tahoma;">Detect HCG(corpus luteum) in blood or urine; Recognition of hCG (or a subunit) by an antibody to the hCG molecule usually the $-subunit of hCG<strong><span style="font-family:Tahoma;"> </span></strong></span>
<ul>
<li class="MsoNormal"><span><strong>Qualitative:</strong>  positive or negative</span>
<ul>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Urine: morning sample is the best; but any will do</span></li>
</ul>
</li>
<li class="MsoNormal"><span><strong>Quantitative:</strong>  provides an amount for hCG</span>
<ul>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Blood test: will give an amount (hCG can be detected in the serum 8-9 days after fertilization; and somewhat later in the maternal urine) &#8211;3 days after pregnancy</span></li>
</ul>
</li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Clinical tests: sensitive at the time of missed menses</span></li>
</ul>
</li>
</ul>
<p><strong><em><span style="font-size:9pt;font-family:Tahoma;">**Objective 3: Describe how to determine last menstrual period and estimated date of delivery</span></em><span style="font-size:9pt;font-family:Tahoma;"></span></strong></p>
<ul>
<li class="MsoNormal"><span><strong>Dating: LMP – 3months + 7 days</strong> </span></li>
<li class="MsoNormal"><span><strong>Nagele’s Rule:</strong> first day of LMP, minus three months, plus one week and one year.  This equal 280 days from LMP.  No research supports 280 days as the length of pregnancy. </span></li>
<li class="MsoNormal"><em><span style="font-size:9pt;font-family:Tahoma;">Example: Dec.1st (so,) Dec.1st-3months=Sept.1st + 7days=Sept.8th</span></em><span style="font-size:9pt;font-family:Tahoma;"></span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Research has shown that the pregnancy mean is closer to 283-284 days from LMP or 269-270 days from ovulation</span></li>
<li class="MsoNormal"><span><strong>Always determine if LMP was a normal period for the woman.</strong> Spotting at the time of implantation is not uncommon.  This scanty bleeding may be interpreted as a period unless a through menstrual history is obtained.  Remember, LMP refers to the first day of her last </span><span style="font-size:9pt;font-family:Tahoma;">NORMAL</span><span style="font-size:9pt;font-family:Tahoma;"> period.  If a woman is a poor historian and has difficulty determining her LMP, it may be useful to use holidays or other events to help her focus her memory.</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;">Gestational Wheel: At the beginning of the wheel is the 1st day of menses; outside of wheel calendar year. middle wheel months; also, 280 marker (40weeks) ex. Sept.10-June 17</span></li>
<li class="MsoNormal"><span style="font-size:9pt;font-family:Tahoma;"><span style="font-size:12pt;"><font face="Times New Roman"><a href="http://sara1hays.files.wordpress.com/2008/02/gestationalwheel.gif" title="Gestational Wheel"></a><span><a href="http://sara1hays.files.wordpress.com/2008/02/gestationalwheel.gif" title="Gestational Wheel"></a><strong><a href="http://sara1hays.files.wordpress.com/2008/02/gestationalwheel1.gif" title="Gestational Wheel"><img src="http://sara1hays.files.wordpress.com/2008/02/gestationalwheel1.thumbnail.gif?w=455" alt="Gestational Wheel" /></a></strong></span></font></span></span></li>
</ul>
<p><span style="font-size:9pt;font-family:Tahoma;"></span><span><strong>DATING METHODS</strong> </span><span><strong>Level 1 – most reliable</strong></span></p>
<ul>
<li>
<div><span></span><span style="font-size:9pt;font-family:Tahoma;">1.  <u>LMP</u> which is normal, regular, &amp; certain (1-2 wk range of accuracy) </span></div>
</li>
<li>
<div><span style="font-size:9pt;font-family:Tahoma;"></span><span style="font-size:9pt;font-family:Tahoma;">2.  <u>Basal body temperature with coital record</u>, showing ovulation &amp; sustained temperature elevation. (2-5 days range of accuracy)</span></div>
</li>
<li>
<div><span style="font-size:9pt;font-family:Tahoma;"></span><span style="font-size:9pt;font-family:Tahoma;">3. <u>Ultrasound between 7 &amp; 10 weeks of menstrual age</u>, using crown-rump length to calculate gestational age. (accurate to within  3-5 days)</span></div>
</li>
<li>
<div><span style="font-size:9pt;font-family:Tahoma;"></span><span style="font-size:9pt;font-family:Tahoma;">4. <u>Serum hCG levels</u> &lt;10,000 on two separate occasions one week apart, rising appropriately. . (accurate to within  3-5 days) </span></div>
</li>
<li>
<div><span style="font-size:9pt;font-family:Tahoma;"></span><span style="font-size:9pt;font-family:Tahoma;">5. <u>Urine pregnancy testing</u>, which may initially be negative, but becomes positive as soon as detectable levels of hCG are present in maternal urine. This timing will vary according to the type of urine test used. </span></div>
</li>
<li>
<div><span style="font-size:9pt;font-family:Tahoma;"></span><span style="font-size:9pt;font-family:Tahoma;">6. <u>Two ultrasounds &lt;26 weeks gestational age</u>, which estimate dates of delivery within 2.6 weeks of each other.  Use the EDD based upon the earlier ultrasound, unless obtained between 10 &amp; 13.      </span></div>
</li>
</ul>
<p></font></span></p>
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		<title>Antepartal Care: Teratology</title>
		<link>http://sara1hays.wordpress.com/2008/02/12/antepartal-care-teratology/</link>
		<comments>http://sara1hays.wordpress.com/2008/02/12/antepartal-care-teratology/#comments</comments>
		<pubDate>Tue, 12 Feb 2008 00:00:13 +0000</pubDate>
		<dc:creator>sara1hays</dc:creator>
				<category><![CDATA[Childbearing Family]]></category>

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		<description><![CDATA[Teratogens (birth defects) any agent or non-genetic factor that produces permanent abnormal embryonic physical development of physiology. Historical Events: 1941: Rubella (blindness, Congenital Heart defects) 1950&#8242;s: Methylmercury (neurotoxicity) 1960&#8242;s: Thalidomide (phocomelia) 1970&#8242;s: Alcohol (fetal alcohol syndrome) Principles of Teratology: All or none phenomenon (from conception to implantation)-prenatal death Dose dependency Critical periods for certain effects [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=sara1hays.wordpress.com&amp;blog=2848151&amp;post=3&amp;subd=sara1hays&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<ul>
<li><strong><a href="http://sara1hays.files.wordpress.com/2008/02/criticalperiodshumandevelopment1.jpg" title="Critical Periods for Human Development"></a></strong><strong>Teratogens</strong> (birth defects) any agent or non-genetic factor that produces permanent abnormal embryonic physical development of physiology.</li>
<li><strong>Historical Events:</strong>
<ul>
<li>1941: Rubella (blindness, Congenital Heart defects)</li>
<li>1950&#8242;s: Methylmercury (neurotoxicity)</li>
<li>1960&#8242;s: Thalidomide (phocomelia)</li>
<li>1970&#8242;s: Alcohol (fetal alcohol syndrome)</li>
</ul>
</li>
<li><strong>Principles of Teratology:</strong>
<ul>
<li>All or none phenomenon (from conception to implantation)-prenatal death</li>
<li>Dose dependency</li>
<li>Critical periods for certain effects</li>
<li>Duration of exposure</li>
<li>Host suseptibility</li>
<li>Drug interactions
<ul>
<li>BEST: Single drug; lowest dose</li>
</ul>
</li>
</ul>
</li>
<li><strong>Critical periods during human development: </strong></li>
<li>Embryonic 3-8weeks; Gestational age 5-10weeks</li>
<li>
<div><a href="http://sara1hays.files.wordpress.com/2008/02/criticalperiodshumandevelopment1.jpg" title="Critical Periods for Human Development"><img src="http://sara1hays.files.wordpress.com/2008/02/criticalperiodshumandevelopment1.thumbnail.jpg?w=455" alt="Critical Periods for Human Development" /></a><a href="http://sara1hays.files.wordpress.com/2008/02/criticalperiodshumandevelopment.jpg" title="Critical Periods of Human Development"></a></div>
</li>
<li>
<div><strong>Effect of teratogen by (gestational) week exposure:</strong></div>
<ul>
<li>
<div>1-6 weeks: CNS</div>
</li>
<li>
<div>2-7 weeks: Heart</div>
</li>
<li>
<div>3-8 weeks: Extremities</div>
</li>
<li>
<div>3-8 weeks: Eyes</div>
</li>
<li>
<div>5-8 weeks: Palate</div>
</li>
<li>
<div>6-10 weeks: External Genitalia</div>
</li>
</ul>
</li>
<li>
<div><strong>Thalidomide:</strong></div>
<ul>
<li>
<div>Introduced in 1956 as a seditive &amp; anti-nausea agent</div>
</li>
<li>
<div>Withdrawn in 1961</div>
</li>
<li>
<div>Discovered to be human teratogen causing absence of limbs or limb malformations in newborns</div>
</li>
<li>
<div>5000-7000 infants effected</div>
</li>
<li>
<div>Resulted in new drug testing rules</div>
</li>
</ul>
</li>
<li>
<div><strong>Pre-Embryonic Stage:</strong></div>
<ul>
<li>
<div>Time of fertilization &amp; up to implantation</div>
</li>
<li>
<div>First 2 weeks of gestation</div>
</li>
<li>
<div>Exposure to teratogens in this period may lead to improper implantation &amp; spontaneous abortion, Also called &#8220;All or None&#8221;.</div>
</li>
</ul>
</li>
<li>
<div><strong>Critical Period- Embryonic Period:</strong></div>
<ul>
<li>
<div>From day 14-18 to day 54-60 post-conception (this is the critical period)</div>
</li>
<li>
<div>Period of most extensive organ differentiation (the heart-first 38days; arms/legs-first 49days; teeth-first 56days, etc.)</div>
</li>
<li>
<div>Exposure to teratogens during this period can cause structural and functionatl birth defects.</div>
</li>
</ul>
</li>
<li>
<div><strong>Fetal Period:</strong></div>
<ul>
<li>
<div>From day 56 of gestation to delivery</div>
</li>
<li>
<div>Differentiation of the palate, external genitalia, and ear are examples for this period. Structural defects as well as fetal growth retardation can occur.</div>
</li>
</ul>
</li>
<li>
<div>Known or strongly suspected Teratogens (Drugs &amp; Chemicals)</div>
<ul>
<li>
<div>Alcohol</div>
</li>
<li>
<div>Androgens (testosterone)</div>
</li>
<li>
<div>ACE Inhibitors (hypertensive medications)</div>
</li>
<li>
<div>Antithyroid medications</div>
</li>
<li>
<div>Coumadin</div>
</li>
<li>
<div>Carbamezepine, Phenytoin, Valproic Acid (cleft palate)</div>
</li>
<li>
<div>Folic Acid Antagonist (Hyper/Hypobilrubemia</div>
</li>
<li>
<div>Cocaine</div>
</li>
<li>
<div>Lead, Mercury+</div>
</li>
<li>
<div>Lithium (Bipolar meds. -cardiac defects)</div>
</li>
<li>
<div>NSAID&#8217;s</div>
</li>
<li>
<div>Tetracycline (discolor teeth/effect bone growth)</div>
</li>
<li>
<div>Thalidomide</div>
</li>
<li>
<div>NO Sulfa-drugs</div>
</li>
</ul>
</li>
<li>
<div><strong>Known or Strongly Suspected Teratogens (INFECTIONS)</strong></div>
<ul>
<li>
<div>CMV-cytomet.virus</div>
</li>
<li>
<div>Rubella</div>
</li>
<li>
<div>Syphilis (Treat w/ PCN-not for babies/PCN desensitizes preg.women) baby bleeds to death</div>
</li>
<li>
<div>Toxoplasmosis</div>
</li>
<li>
<div>Varicella</div>
</li>
</ul>
</li>
<li>
<div><strong>SSRI&#8217;s and Birth Defects (To treat depression)</strong></div>
<ul>
<li>
<div><strong>Paxil</strong>, after 20th.wk, 1st trimester</div>
<ul>
<li>
<div>Persistant Pulmonary Hypertension; taken after 20th wk; respiratory problems; 6 times greater risk</div>
</li>
<li>
<div>RR of atrial and ventricular septal defects w/ 1st trimester use; fetal echocardiography to screen in women exposed</div>
</li>
</ul>
</li>
<li>
<div><strong>Prozac</strong>, third trimester use</div>
<ul>
<li>
<div>preterm delivery, respiratory difficulty, admission to NICU, jitteriness</div>
</li>
</ul>
</li>
<li>
<div>JAMA, May 2008: SSRI&#8217;s-late in preg-3times greater risk-respiratory prob. in newborns (including <strong>Effexor</strong>)</div>
</li>
<li>
<div>FDA Category D</div>
</li>
</ul>
</li>
<li>
<div><strong>FDA Categories:</strong></div>
<ul>
<li>
<div>A: Controlled studies in humans/ but not shown an increased risk for BD&#8217;s</div>
</li>
<li>
<div>B: Animal studies show negative for BD&#8217;s/no adequate human studies OR animal/human studies not available</div>
</li>
<li>
<div>C: Animal Studies show risk/ lack in human data</div>
</li>
<li>
<div>D: Human data-show risk (benefit may outweigh)</div>
</li>
<li>
<div>X: Animal/Human data positive</div>
</li>
</ul>
</li>
<li>
<div>Smoking in Pregnancy</div>
<ul>
<li>
<div>Associated with reduced birth weight (IUGR &amp; LBW), pematurity, stillborn, placental abruption</div>
</li>
</ul>
</li>
<li>
<div>Fetal Alcohol Syndrome (FAS)</div>
<ul>
<li>
<div>First described in 1970s</div>
</li>
<li>
<div>Facial abnml, growth retardation, CNS effects, reduced intelligence</div>
</li>
<li>
<div>Facial effects: microcephaly, flat face, thin lips, missing groove above lip, short nose</div>
</li>
<li>
<div>Effects 4-12 thousand infants per year</div>
</li>
<li>
<div>Fetal Alcohol effects: (FAE) milder form but still CNS involvement</div>
</li>
</ul>
</li>
</ul>
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